Endocrine Abstracts

Introduction: Long term control of glucotoxicity has been shown to increase the secretion of insulin and C-peptide (Cp) from beta cells. However, there is limited data concerning the effect of short term glycemic control and reversal of glucotoxicity on basal Cp. We aimed to investigate the change in serum Cp levels after short term glycemic control in patients with uncontrolled type 2 diabetes mellitus (DM).Materials and methods: A total of 123 patients...

The most frequent pathology of primary hyperparathyroidism presented with the findings of hypercalcemia is parathyroid adenoma. Some patients having the signs of primary hyperparathyroidism may have intrathyroidal parathyroid adenoma and it may be overlooked. We present a case of intrathyroidal parathyroid adenoma presented with bone pain.47-year-old female patient referred to our clinics with bone pain and she had no pruritus, dry mouth, dyspepsia, abdo...

Introduction: Incretin based therapeutics have commonly been used in the last years for the management of patients with type 2 diabetes mellitus (DM). Linagliptin is a member of “dipeptidyl peptidase 4” (DPP-4) inhibitors and often preferred owing to some advantages over the others. We present a diabetic case developing skin findings after the initiation of linagliptin.Case: 66 year-old woman with a history of type 2 DM for 10 years was admitte...

Introduction: Most of the human studies suggested an association between obesity and low 25(OH)D3 0levels. It has been proposed that co-existence of vitamin D deficiency may have a role in the development of IR in obesity. We aimed to reveal whether any association was present between IR and 25(OH)D3.Materials-methods: 223 obese patients referred to our clinics were evaluated for the study. 24 patients with known diabetes mellitus were excluded. Finally,...

Aims: Bening and malignant thyroid nodules are the most common lesions of endocrine glands. Some molecular markers; Mut-S homolog-2 (MSH2) and Mut-L-homolog-1 (MLH1) are the two of DNA repair proteins and metil guanin–DNA-metil transferase (MGMT) is the DNA repair enzymes have been studied. In this study, our aim is to evaluate MSH2, MLH1, and MGMT levels in papillary thyroid cancer (PTC), multinodular colloidal goitre (MNG), and chronic lymphocytic thyroiditis (CLT) and ...

Aims: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) increase the risk for diabetic ketoacidosis, particularly in patients with type 1 diabetes (T1DM). We aimed to determine whether SGLT2i use increase the risk of euglycemic diabetic ketoacidosis (euDKA) and to indicate its demographic, clinical features.Methods: We performed a retrospective cohort study of 51 patients over 18 years-old admitted to emergency unit at a tertiary care hospital from 2018...

Introduction: U-300 insulin glargine has been used as a concentrated form of glargine. Skin and subcutaneous tissue disorders (eg, rash, pruritus, and urticaria) have been reported with insulin glargine. But to our knowledge, maculopapular rash has not been reported with use of U-300 insulin glargine. We present a patient with type 1 diabetes mellitus(DM) developing maculopapular rash after initiation of U-300 glargine insulin.Case Report: 37 year-old fe...

Introduction: The frequency of new-onset diabetes after transplant (NODAT) is 5–30% in liver transplant recipients. We aimed to analyze the frequency and predictors of NODAT in the patients undergoing liver transplantation (LTx) due to acute liver failure(ALF), and to investigate whether pretransplant hypoglycemia had any effect on NODAT.Materials and methods: Adult patients undergoing LTx due to ALF were analyzed retrospectively. The patients with...

Introduction: Studies investigating the association between serum IGF-1, and thyroid nodule, ovarian or thyroid volume in polycystic ovarian syndrome (PCOS) are limited. We aimed to analyze the association between serum IGF-1 level, and ovarian or thyroid volume, or thyroid nodule in PCOS.Materials and methods: The study was performed between June 2017 and August 2019 as prospective design. The patients referred to our medical faculty were included. Adul...

Purpose: The coronavirus disease 2019 (COVID-19) has a high morbidity and mortality in patients with chronic disorders. This study was aimed at assessing the frequency and outcomes of COVID-19 in patients with lipodystrophy syndrome and investigating the effect of restricted access to the hospital during pandemic on metabolic parameters.Methods: A survey comprising descriptive questions about the situation of the patients during the COVID-19 pandemic was...